Impairments of Speech Fluency in Lewy Body Spectrum Disorder

Autor/inn/en	Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray
Titel	Impairments of Speech Fluency in Lewy Body Spectrum Disorder
Quelle	In: Brain and Language, 120 (2012) 3, S.290-302 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0093-934X
DOI	10.1016/j.bandl.2011.09.004
Schlagwörter	Dementia; Patients; Neurological Impairments; Speech Language Pathology; Executive Function; Grammar; Brain Hemisphere Functions; Sentences; Oral Language; Speech Evaluation; Correlation; Regression (Statistics); Connected Discourse; Language Processing; Speech Impairments + Suchen Sie Ihr Suchwort? Demenz; Patient; Neurodegenerative Erkrankung; Grammatik; Sentence analysis; Satzanalyse; Oral interpretation; Mündlicher Sprachgebrauch; Korrelation; Regression; Regressionsanalyse; Sprachverarbeitung; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung
Abstract	Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions. (Contains 9 tables and 4 figures.) (As Provided).
Anmerkungen	Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10